Research Articles
Teleological Thinking in Biomedicine: From Cognitive Bias to Innovation Catalyst in Drug Development
This article explores the dual role of intuitive teleological concepts—the cognitive bias to attribute purpose and goal-directedness to biological entities and processes—within biomedical research and drug development.
Teleology as a Cognitive Constraint in Biology Education: From Foundational Bias to Research Applications
Teleological reasoning—the cognitive bias to explain phenomena by their purpose or function—is a pervasive and persistent constraint on accurate biological understanding.
From Final Causes to Natural Selection: The Evolving History of Teleology in Evolutionary Biology
This article traces the complex history of teleological thinking in evolutionary biology, from its Aristotelian origins to contemporary debates.
Metacognitive Vigilance: A Framework to Counteract Teleological Reasoning in Scientific and Drug Development Research
This article explores the critical role of metacognitive vigilance—the awareness and regulation of one's own thought processes—in mitigating teleological reasoning, the cognitive bias to explain phenomena by their purpose rather...
Teleological Thinking in Science: Unraveling Cognitive Barriers to Accurate Conceptual Understanding in Research and Education
This article examines the pervasive role of teleological thinking—the cognitive bias to ascribe purpose to natural phenomena—in fostering scientific misconceptions among students and professionals.
Root Mean Square Fluctuation (RMSF) in Molecular Dynamics: A Comprehensive Guide for Validation and Biomolecular Analysis
Root Mean Square Fluctuation (RMSF) is a critical metric in Molecular Dynamics (MD) simulations for quantifying local protein flexibility and validating simulation stability.
Molecular Dynamics Trajectory Quality Assessment: From Foundational Principles to Advanced Validation in Biomedical Research
This comprehensive article explores current methodologies and best practices for assessing the quality of molecular dynamics (MD) trajectories, a critical challenge in computational biophysics and drug development.
Validating Molecular Dynamics Thermodynamic Properties: From Foundational Principles to AI-Enhanced Workflows in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on the validation of thermodynamic properties derived from Molecular Dynamics (MD) simulations.
GROMACS vs AMBER vs NAMD: A 2025 Comparative Guide for Molecular Dynamics Simulations
This article provides a comprehensive, up-to-date comparison of the three leading molecular dynamics software packages—GROMACS, AMBER, and NAMD—tailored for researchers, scientists, and drug development professionals.
Validating Protein-Ligand Binding with Molecular Dynamics: A Comprehensive Guide from Theory to Practice
This article provides a comprehensive framework for researchers and drug development professionals to validate protein-ligand binding using Molecular Dynamics (MD) simulations.