Research Articles
Computational Simulation of Genetic Code Robustness: From Evolutionary Insights to Therapeutic Applications
This article explores the critical role of computational simulation in quantifying the robustness of the genetic code and its profound implications for biomedical research.
De Novo Drug Design in 2025: A Comparative Guide to AI Methods, Benchmarks, and Clinical Applications
This article provides a comprehensive comparison of modern de novo drug design methods for researchers and drug development professionals.
Beyond Neutral Theory: Validating Predictions in Molecular Evolutionary Ecology for Biomedical Research
This article synthesizes recent breakthroughs in molecular evolutionary ecology to address the critical challenge of validating predictive models.
Reductionism vs Holism in Molecular Biology: Bridging Approaches for Advanced Biomedical Research
This article provides a comprehensive analysis of reductionist and holistic methodologies in molecular biology, tailored for researchers, scientists, and drug development professionals.
Comparative Transcriptomics Across Species: From Evolutionary Insights to Clinical Applications
This article provides a comprehensive overview of the field of comparative transcriptomics, exploring how the comparison of gene expression across species is revolutionizing our understanding of biology, disease, and therapeutic...
Fossil Calibration in Molecular Clock Dating: Validation Methods, Challenges, and Best Practices for Evolutionary Research
This article provides a comprehensive overview of the critical role of fossil calibration in validating molecular clock models for estimating evolutionary timescales.
Comparative Analysis of Antibiotic Resistance Genes: Methodologies, Challenges, and Clinical Implications
This article provides a comprehensive comparative analysis of current methodologies for detecting and analyzing Antibiotic Resistance Genes (ARGs), a critical challenge in global health.
Resurrecting the Past for Future Cures: A Modern Guide to Validating Ancestral Protein Functions In Vivo
Ancestral protein reconstruction (APR) has emerged as a powerful tool for understanding molecular evolution and engineering novel biologics.
Beyond AlphaFold: Benchmarking Evolutionary Algorithms Against Machine Learning for Novel Protein Folding and Design
This article provides a comprehensive benchmark of Evolutionary Algorithms (EAs) and Machine Learning (ML) models for protein structure prediction and design.
Optimizing Molecular Diagnostics for Diabetic Foot: Integrating Biomarkers, Machine Learning, and Novel Targets
This article synthesizes cutting-edge advancements in molecular diagnostics for diabetic foot complications, addressing the critical need for precise, non-invasive tools.